ASSESSMENT OF GENETIC INTEGRITY, SPLENIC PHAGOCYTOSIS AND CELL DEATH POTENTIAL OF (Z)-4-((1,5-DIMETHYL-3-OXO-2-PHENYL-2,3DIHYDRO-1H-PYRAZOL-4-YL) AMINO)-4-OXOBUT-2-ENOIC ACID AND ITS EFFECT WHEN COMBINED WITH COMMERCIAL CHEMOTHERAPEUTICS

Abstract The increased incidence of cancer and its high treatment costs have encouraged the search for new compounds to be used in adjuvant therapies for this disease.This study discloses the synthesis of (Z)-4-((1,5-dimethyl-3-oxo-2-phenyl-2,3dihydro-1H-pyrazol-4-yl) amino)-4-oxobut-2-enoic acid (IR-01) and evaluates not only the action of this co

Computational modeling has become a prominent tool to simulate physical processes for research and development projects.The coastal region of southern Brazil is very susceptible to oil spill accidents.Currently, oil is intensively transported in the region due to the presence of the Rio Grande Harbor, the Transpetro Waterway Terminal (Petrobras) an

The main objective of this research was to evaluate the impact of methanolic, ethanolic and aqueous extracts Earl Grey Tea of Origanum majorana L., Origanum vulgare L., Teucrium chamaedrys L., Teucrium montanum L., Thymus serpyllum L.and Thymus vulgaris L.(Lamiaceae) on the effects of free radicals using different model systems.The extracts were ch

The aim of this study was to determine the acute metabolic effects of different magnitudes of wearable resistance (WR) attached to the thigh during submaximal running.Twenty endurance-trained runners (40.8 ± 8.2 years, 1.77 ± 0.7 m, 75.4 ± 9.2 kg) completed six submaximal eight-minute running trials unloaded and with WRs of 1%, 2%, 3

In this paper, we present an electro-optical modulator based on graphene absorption.In this structure, graphene is placed on aluminum oxide, the structure of which is repeated alternately.This alternating structure of graphene on aluminum oxide is located inside a semi-cylindrical cavity in a 1-dimensional photonic crystal nanobeam cavity.Unlike pr